Water-stable catalyst could bring carbon-bond chemistry closer to use in living cells

Olefin metathesis is one of the most important reactions in organic chemistry for forming carbon–carbon bonds—for example, in the production of pharmaceuticals, plastics and complex natural products. However, previous ruthenium catalysts that enable this reaction have faced a major challenge: They rapidly degrade in aqueous or biological environments, making their use in natural systems such as cells or blood extremely difficult.