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Sawbones: Colonoscopy

In honor of Justin's first colonoscopy, Dr. Sydnee goes through the history of looking inside the colon. From Pompei to the Light Conductor to the more flexible tubes today, humans have always been curious to see just what's going on up there. Music: "Medicines" by The Taxpayers https://taxpayers.bandcamp.com/ Immigrant Defenders Law Center: https://www.immdef.org/ Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joinsawbones

Published Aug 16, 2026 · 7:24 AMOriginal source: Sawbones: A Marital Tour of Misguided Medicine5 reads
In honor of Justin's first colonoscopy, Dr. Sydnee goes through the history of looking inside the colon. From Pompei to the Light Conductor to the more flexible tubes today, humans have always been curious to see just what's going on up there.

Music: "Medicines" by The Taxpayers https://taxpayers.bandcamp.com/

Immigrant Defenders Law Center: https://www.immdef.org/

Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joinsawbones
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Sawbones: A Marital Tour of Misguided Medicine

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Our Unnatural Selection

Humans have been altering animals for millennia. We select the most docile livestock, the most loyal dogs, to breed the animals we need. This 'artificial selection' is intentional. But as Adam Hart discovers, our hunting, fishing and harvesting are having unintended effects on wild animals - the age of "unnatural selection". This accidental, inadvertent or unintentional selection pressure comes form almost everything we do – from hunting, fishing, harvesting and collecting to using chemicals like pesticides and herbicides; then pollution; urbanisation and habitat change, as well as using medicines. All these activities are putting evolutionary pressures on the creatures we share our planet with.Commercial fishing selects the biggest fish in the oceans, the biggest fish in a population, like Atlantic cod, are also the slowest to reach breeding maturity. When these are caught and taken out of the equation, the genes for slow maturity and ‘bigness’ are taken out of the gene pool. Over decades, this relentless predation has led to the Atlantic cod evolving to be vastly smaller and faster to mature. Trophy hunting is another example of unnatural selection. Predators in the wild tend to pick off the easiest to catch, smallest, youngest or oldest, ailing prey. But human hunters want the biggest animals with the biggest antlers or horns. Big Horn Sheep in Canada have evolved to have 25% smaller horns due to hunting pressures.Probably the best understood examples of unnatural selection are the evolution of antibiotic resistance in bacteria. By using antibiotics we are inadvertently selecting the bacteria that have resistance to the drugs. The same goes for agricultural pesticides and herbicides.Even pollution in Victorian times led to the Peppered moth to change its colour.Adam

Original sourceDiscovery
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Science Stories: Series 2 - Margaret Cavendish

In the spring of 1667 Samuel Pepys queued repeatedly with crowds of Londoners and waited for hours just to catch a glimpse of aristocrat writer and thinker Margaret Cavendish. Twice he was frustrated and could not spot her, but eventually she made a grand visit to meet the Fellows of the newly formed Royal Society. She was the first woman ever to visit.Pepys watched as they received her with gritted teeth and fake smiles. They politely showed her air pumps, magnets and microscopes, and she politely professed her amazement, then left in her grand carriage. Naomi Alderman asks what it was it about this celebrity poet, playwright, author, and thinker that so fascinated and yet also infuriated these men of the Restoration elite? Part of the answer strikes right at the core of what we now call the scientific method. (Photo: Book cover of Grounds of Natural Philosophy, courtesy of Chemical Heritage Foundation)

Original sourceDiscovery
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Science Stories: Series 2 - Orgueil Meteorite

In 1864 a strange type of rock fell from the sky above Orgueil in rural France. Shocked and frightened locals collected pieces of the peculiar, peaty blob from the surrounding fields, and passed them on to museums and scientists. At that time, a debate had been raging over the origin of life; Could life possibly form from mere chemicals? Or did it need some strange unidentified vital substance?Into this debate fell the Orgueil meteorite, and because it seemed remarkably similar to loamy soil, some wondered whether it may hint at the existence of extra-terrestrial life.The great Pasteur allegedly investigated, but disappointingly found no such thing. Nevertheless, the mere possibility prompted later ideas that the origin of life on earth indeed lay elsewhere in the universe, ideas that were greeted with varying degrees of scepticism over ensuing decades.As Phil Ball narrates, given how much was at stake, and how bitterly scientists argued on either side, the most remarkable thing about the story is the extraordinary secret the meteorite kept to itself until exactly 100 years later. Producer: Alex MansfieldImage: These faint shapes found in meteorite AH844001 found in Antarctica were, until quite recently, thought by some to be alien fossils. But thoughts of extra-terrestrial life being carried in such meteorites goes back at least as far as 19th century France. BBC Copyright

Original sourceDiscovery