BPrecede Biosciences Presents ESMO 2026 Data Revealing Biology Associated with Response and Resistance to PSMA-Directed Radioligand Therapy in Advanced Prostate Cancer
Baseline plasma profiling identified three molecular states previously characterized in tissue: androgen receptor (AR)-high/metabolic, stem/epithelial–mesenchymal transition (EMT), and AR-low/proliferative. The AR-high/metabolic group showed the most favorable outcome trends. Analysis of published gene sets corroborated these findings: higher stem-like and WNT signaling activity was associated with shorter time to next treatment, while higher AR signaling and […]
Baseline plasma profiling identified three molecular states previously characterized in tissue: androgen receptor (AR)-high/metabolic, stem/epithelial–mesenchymal transition (EMT), and AR-low/proliferative. The AR-high/metabolic group showed the most favorable outcome trends. Analysis of published gene sets corroborated these findings: higher stem-like and WNT signaling activity was associated with shorter time to next treatment, while higher AR signaling and […]
Financial Post
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